Hemophagocytic syndrome associated with retinoic acid syndrome in acute promyelocytic leukemia
نویسندگان
چکیده
منابع مشابه
Retinoic acid syndrome in patients following the treatment of acute promyelocytic leukemia with all-trans retinoic acid.
BACKGROUND Retinoic acid syndrome (RAS) is a potentially lethal complication during all-trans retinoic acid (ATRA) treatment of acute promyelocytic leukemia (APL). The incidence and risk factors have been shown to vary in different series. In this study we want to establish the incidence of RAS in our hospital and try to elucidate factors that increase its risk. METHODS We retrospectively ana...
متن کاملClinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.
We examined the incidence, clinical course, and outcome of patients with newly diagnosed acute promyelocytic leukemia (APL) who developed the retinoic acid syndrome (RAS) treated on the Intergroup Protocol 0129, which prospectively evaluated the role of alltrans retinoic acid (ATRA) alone during induction and as maintenance therapy. Forty-four of 167 (26%) patients receiving ATRA for induction ...
متن کاملSweet’s syndrome during the treatment of acute promyelocytic leukemia with all-trans retinoic acid
All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Quite many ATRA-related side effects, including retinoic acid syndrome, were reported. So far, it has rarely been reported that Sweet's syndrome, characterized by fever, neutrophilia, painful erythematous cutaneous plaques, dense dermal infiltrates of mature neutrophils and rapid response ...
متن کاملAcute polymyositis associated with hemophagocytic lymphohistiocytosis syndrome
Background Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease in which an exaggerated but ineffective immune response leads to severe hyper inflammation. It commonly affects infants from birth to 18 months of age, but cases in older children and adults have also been reported. Key players in HLH are activated lymphocytes and histiocytes, they infiltrate all organs and secret...
متن کاملNephrotic syndrome in acute promyelocytic leukemia
A five-year-old boy presented (Day 0) with gingival bleeding and pancytopenia (white blood cells: 1.7 × 10/L; hemoglobin: 7.3 g/dL; platelets: 16 × 10/L). A coagulation panel was unremarkable. Peripheral blood smear revealed dysmorphic promyelocytes with red-blue granules, folded reniform nuclei and no Auer rods. Bone marrow examination showed immature myeloid cells (>60% promyelocytes) that we...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2004
ISSN: 0361-8609
DOI: 10.1002/ajh.20071